Publications

Enantioselectivity in Metabolism and Toxicity of 6PPD-Quinone in Salmonids 

Pranav Nair, Jianxian Sun, Linna Xie, Lisa Kennedy, Derek Kozakiewicz, Sonya M. Kleywegt, Chunyan Hao, Hannah Byun, Holly Barrett, Joshua Baker, Joseph Monaghan, Erik T. Krogh, Datong Song, and Hui Peng

Environmental Science & Technology 2025 59 (15), 7485-7494

DOI: 10.1021/acs.est.4c12220 

Structure and Toxicity Characterization of Alkyl Hydroxylated Metabolites of 6PPD-Q 

Pranav Nair#, Holly Barrett#, Kaylin Tanoto, Linna Xie, Jianxian Sun, Diwen Yang, Han Yao, Datong Song, and Hui Peng

Environmental Science & Technology 2025 59 (15), 7474-7484

DOI: 10.1021/acs.est.4c11823 

Structurally Selective Ozonolysis of p-Phenylenediamines and Toxicity in Coho Salmon and Rainbow Trout 

Linna Xie, Jie Yu, Pranav Nair, Jianxian Sun, Holly Barrett, Oliver Meek, Xing Qian, Diwen Yang, Lisa Kennedy, Derek Kozakiewicz, Chunyan Hao, John D. Hansen, Justin B. Greer, Jonathan P. D. Abbatt, and Hui Peng

Environmental Science & Technology 2024 58 (49), 21423-21432

DOI: 10.1021/acs.est.4c04817 

Compound Class-Specific Temporal Trends (2021–2023) of Tire Wear Compounds in Suspended Solids from Toronto Wastewater Treatment Plants 

Linna Xie, Lai Yuan, Jianxian Sun, Minqing Ivy Yang, Ismail Khan, Jhoselyn Jaramillo Lopez, Yufeng Gong, Pranav Nair, Chunyan Hao, Paul Helm, Holly Barrett, Elizabeth A. Edwards, and Hui Peng

ACS ES&T Water 2024 4 (12), 5708-5719

DOI: 10.1021/acsestwater.4c00705 

Unique hepatic maternal transfer pattern of trace metals and perfluoroalkyl substances (PFAS) in a bluntnose sixgill shark (Hexanchus griseus) 

Misha Zvekic, Holly Barrett, Peter Diamente, Hui Peng, Erik T. Krogh

Chemosphere, Volume 359, 2024, 142315

DOI: 10.1016/j.chemosphere.2024.142315

Identification of hydrocarbon sulfonates as previously overlooked transthyretin ligands in the environment 

Yufeng Gong, Jianxian Sun, Xiaoyun Wang, Holly Barrett, and Hui Peng

Environmental Science & Technology 2024 58 (23), 10227-10239

DOI: 10.1021/acs.est.3c10973 

The association between per-/polyfluoroalkyl substances in serum and thyroid function parameters: A cross-sectional study on teenagers living near a Chinese fluorochemical industrial plant 

Lin-Na Xie, Xiao-Chen Wang, Li-Qin Su, Sai-Sai Ji, Wen Gu, Holly Barrett, Xiao-Jie Dong, Hui-Juan Zhu, Sha-Sha Hou, Zhen-Huan Li, Yi-Lin Liu, Ling Zhang, Ying Zhu

Science of The Total Environment, Volume 920, 2024, 170985

DOI: 10.1016/j.scitotenv.2024.170985

Diindoles produced from commensal microbiota metabolites function as endogenous CAR/Nr1i3 ligands 

Jiabao Liu, Ainaz Malekoltojari, Anjana Asokakumar, Vimanda Chow, Linhao Li, Hao Li, Marina Grimaldi, Nathanlown Dang, Holly Barrett, Jhenielle Campbell, William Navarre, Derek Wilson, Hongbing Wang, Sridhar Mani, Patrick Balaguer, Hui Peng, Sayeepriyadarshini Anakk, Henry Krause

Nature Communications 2024, 15(1), 2563

DOI: 10.1038/s41467-024-46559-3 

Emerging investigator series: nontargeted screening of aryl hydrocarbon receptor agonists in endangered beluga whales from the St. Lawrence Estuary: beyond legacy contaminants*

Holly Barrett, Jianxian Sun, Yuhao Chen, Jonathan Verreault, Magali Houde, Frank Wania, Hui Peng

Environmental Science: Processes & Impacts, 2024, 26, 1451–1464.

*Featured on journal cover; selected as a “HOT article” due to receiving particularly high scores at peer review. 

DOI: 10.1039/D4EM00243A

Disclosing environmental ligands of L-FABP and PPARγ: Should we re-evaluate the chemical safety of hydrocarbon surfactants? 

Yufeng Gong, Diwen Yang, Jiabao Liu, Holly Barrett, Jianxian Sun, and Hui Peng

Environmental Science & Technology 2023 57 (32), 11913-11925

DOI: 10.1021/acs.est.3c02898 

Effects of Triclosan on the Development of Antimicrobial Resistance in the Environment: A Review 

Min Yang Chunzhen Wang, Shihai Liu, Haodi Feng, Holly Barrett, Hui Peng, S. H. P. Parakrama Karunaratne, Yu Zhang

Curr Pollution Rep 2023, 9, 454–467.

DOI: 10.1007/s40726-023-00270-x 

Building the environmental chemical-protein interaction network (eCPIN): An exposome-wide strategy for bioactive chemical contaminant identification 

Yufeng Gong, Diwen Yang, Holly Barrett, Jianxian Sun, and Hui Peng

Environmental Science & Technology 2023 57 (9), 3486-3495

DOI: 10.1021/acs.est.2c02751 

Synthetical effect of microplastics and chiral drug amphetamine on a primary food source algae Chlorella pyrenoids 

Han Qu, Fang Wang, Holly Barrett, Bin Wang, Jiajun Han, Junxue Wu, Xiaochen Huang, Yongxia Hu, Gang Yu

Food and Chemical Toxicology, Volume 169, 2022, 113415

DOI: 10.1016/j.fct.2022.113415

Defining the Chemical Additives Driving In Vitro Toxicities of Plastics 

Wanzhen Chen, Yufeng Gong, Michael McKie, Husein Almuhtaram, Jianxian Sun, Holly Barrett, Diwen Yang, Menghong Wu, Robert C. Andrews, and Hui Peng

Environmental Science & Technology 2022 56 (20), 14627-14639

DOI: 10.1021/acs.est.2c03608 

Measuring Perfluoroalkyl Acid Contamination at a Local Hot Spot: An Authentic Field-Based Laboratory Experience in a Senior Analytical Environmental Chemistry Course 

Shira Joudan, Holly Barrett, Amila O. De Silva, Shane R. de Solla, Hui Peng, and Jessica C. D’eon

Journal of Chemical Education 2022 99 (12), 4032-4042

DOI: 10.1021/acs.jchemed.2c00290 

Triclosan is the predominant antibacterial compound in Ontario sewage sludge 

Holly Barrett, Jianxian Sun, Yufeng Gong, Paul Yang, Chunyan Hao, Jonathan Verreault, Yu Zhang, and Hui Peng

Environmental Science & Technology 2022 56 (21), 14923-14936

DOI: 10.1021/acs.est.2c00406 

Behaviors and trophodynamics of o, p′-dichlorodiphenyltrichloroethane (o, p′-DDT) in the aquatic food web: Comparison with p, p′-DDT 

Jianxian Sun, Chenke Xu, Hui Peng, Yi Wan, Kai Luo, Holly Barrett, Jianying Hu

Science of The Total Environment, Volume 821, 2022, 153447

DOI: 10.1016/j.scitotenv.2022.153447

Ecological role of 6OH-BDE47: Is it a chemical offense molecule mediated by enoyl-ACP reductases? 

Jianxian Sun, Holly Barrett, David Ross Hall, Steven Kutarna, Xiaoqin Wu, Yan Wang, and Hui Peng

Environmental Science & Technology 2022 56 (1), 451-459

DOI: 10.1021/acs.est.1c05718 

A Roadmap to the Structure-Related Metabolism Pathways of Per- and Polyfluoroalkyl Substances in the Early Life Stages of Zebrafish (Danio rerio) 

Jiajun Han, Wen Gu, Holly Barrett, Diwen Yang, Song Tang, Jianxian Sun, Jiabao Liu, Henry M Krause, Keith A Houck, Hui Peng

Environ Health Perspect. 2021 Jul 21;129(7):077004

DOI: 10.1289/EHP7169

Application of biochar: An approach to attenuate the pollution of the chiral pesticide fipronil and its metabolites in leachate from activated sludge 

Wenwen Gong, Holly Barrett, Yongxia Hu, Jiajun Han, Fang Wang, Wei Wang, Shuangxi Zhou, Han Qu

Process Safety and Environmental Protection 2021, Volume 149, 936-945

DOI: 10.1016/j.psep.2021.03.044

Co-occurrence of antiseptic triclocarban and chiral anti-inflammatory ibuprofen in environment: Association between biological effect in sediment and risk to human health 

Han Qu, Holly Barrett, Bin Wang, Jiajun Han, Fang Wang, Wenwen Gong, Junxue Wu, Wei Wang, Gang Yu

Journal of Hazardous Materials, 2020, Volume 407, 124871

DOI: doi.org/10.1016/j.jhazmat.2020.124871

Suspect and nontarget screening revealed class-specific temporal trends (2000–2017) of poly-and perfluoroalkyl substances in St. Lawrence Beluga Whales 

Holly Barrett, Xuan Du, Magali Houde, Stéphane Lair, Jonathan Verreault, and Hui Peng

Environmental Science & Technology 2021 55 (3), 1659-1671

DOI: 10.1021/acs.est.0c05957 

Nationwide biomonitoring of neonicotinoid insecticides in breast milk and health risk assessment to nursing infants in the Chinese population 

Dawei Chen, Zhibin Liu, Holly Barrett, Jiajun Han, Bing Lv, Yan Li, Jingguang Li, Yunfeng Zhao, Yongning Wu

Journal of Agricultural and Food Chemistry 2020 68(47), 13906-13915

DOI: 10.1021/acs.jafc.0c05769

How microplastics affect chiral illicit drug methamphetamine in aquatic food chain? From green alga (Chlorella pyrenoidosa) to freshwater snail (Cipangopaludian cathayensis) 

Han Qu, Ruixue Ma, Holly Barrett, Bin Wang, Jiajun Han, Fang Wang, Pin Chen, Wei Wang, Guilong Peng, Gang Yu

Environment International 2020 136, 105480

DOI: 10.1016/j.envint.2020.105480

Nationwide biomonitoring of neonicotinoid insecticides in breast milk and health risk assessment to nursing infants in the Chinese population 

Dawei Chen, Zhibin Liu, Holly Barrett, Jiajun Han, Bing Lv, Yan Li, Jingguang Li, Yunfeng Zhao, Yongning Wu

Journal of Agricultural and Food Chemistry 2020 68(47), 13906-13915

DOI: 10.1021/acs.jafc.0c05769